Bruce Mazer, MD, Executive Director/Chief Scientific Officer (CSO) of the Research Institute of the McGill University Health Centre (RI-MUHC) (Interim) and Head of Child Health Research at the Montreal Children's Hospital (MCH) of the MUHC

Allergy and Immune Tolerance Laboratory
Fun fact about me 

I play guitar and sing, and I love to travel.

I love working with children and their families because 
Children are amazing; sick or well they are always sunny and positive!

Hospital information

Academic appointments 

Professor of Pediatrics and associate member, Division of Experimental Medicine, Department of Medicine, McGill University 

Associate Chair of Research, Department of Pediatrics

Other appointments 

Chairman, Grants Committee, Canadian Allergy, Asthma and Immunology Foundation

Education

University 

Columbia University Jewish Theological Seminary of America

Medical Degree 

McGill University

Residency 

Pediatrics, Montreal Children's Hospital, McGill University

Fellowship(s) 

Pediatric Allergy and Immunology, National Jewish Health Center, Univesrity of Colorado, Denver, CO

Research

Research interests 

Asthma and food allergies affect almost 20% of children in North America. These diseases are important causes of morbidity and mortality, and have a huge economic and social impact. My laboratory uses a combination of human studies and animal modeling to determine new ways of changing the immune response to allergens, and to help to naturally shape immune tolerance in individuals with allergies and asthma.  

Research foci 
  • Modulation of immune responses with intravenous immune globulin;
  • Dissection of regulatory B-cell responses in allergy;
  • Understanding T- and B-cell cross-talk through novel approaches to immune synapse formation;
  • Antigen processing by dendritic cells;
  • Production and modification of immunoglobulin in humans and mice;
  • How IgG acts as a bridge between innate and adaptive immunity.
Keywords 

Asthma, food allergy, immune therapies, intravenous immunoglobulin, B-lymphocytes and mucosal responses, antigen presentation, IgE, IVIg, semaphorins

Awards and distinctions 

2010 Immunology Research Award from the Canadian Society of Allergy and Clinical Immunology

2006-2011 Chercheur national from the Fonds de recherche du Québec–Santé

Selected publications 

Massoud AH, Yona M, Xue D, Chouiali F, Alturaihi H, Ablona A, Mourad W, Piccirillo CA, Mazer BD. Dendritic cell immunoreceptor: A novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells. J Allergy Clin Immunol. 2013 Nov 7. pii: S0091-6749(13)01476-0. doi: 10.1016/j.jaci.2013.09.029. [Epub ahead of print]

Massoud AH, Guay J, Shalaby KH, Bjur E, Ablona A, Chan D, Nouhi Y, McCusker CT, Mourad MW, Piccirillo CA, Mazer BD. Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3-positive regulatory T cells. J Allergy Clin Immunol. 2012 Jun; 129(6):1656-1665.e3. Epub 2012 May 5.

Kaufman GN, Massoud AH, Audusseau S, Banville-Langelier AA, Wang Y, Guay J, Garellek JA, Mourad W, Piccirillo CA, McCusker C, Mazer BD. Intravenous immunoglobulin attenuates airway hyperresponsiveness in a murine model of allergic asthma. Clin Exp Allergy 2011 May; 41(5):718-28. doi: 10.1111/j.1365-2222.2010.03663.x. Epub 2011 Jan 24.

Vazquez-Tello A, Halwani R, Li R, Nadigel J, Bar-Or A, Mazer BD, Eidelman DH, Al-Muhsen S, Hamid Q. IL-17A and IL-17F expression in B lymphocytes. Int Arch Allergy Immunol. 2012; 157(4):406-16. Epub 2011 Nov 25.

Drolet JP, Frangie H, Guay J, Hajoui O, Hamid Q, Mazer BD. B lymphocytes in inflammatory airway diseases. Clin Exp Allergy 40(6):841-9, 2010 [Review].