Larry C. Lands, MD, PhD; Director, Pediatric Respiratory Medicine, Pediatric Cystic Fibrosis Clinic, and Pediatric Pulmonary Function Laboratory

Pulmonology; Pediatric Pulmonary Function Laboratory
Fun fact about me 

I have a comic book collection.

I love working with children and their families because 
I enjoy listening to all the giggling.

Hospital information

Academic appointments 

Professor, Department of Pediatrics, Faculty of Medicine, McGill University

Other appointments 

Canadian Thoracic Soceity Research Strategy Committee and American Thoracic Society Pediatric International Relations Committee

Education

University 

B.Sc., Mathematics Major, Biology Minor, McGill University; PhD, Medical Sciences, McMaster University

Medical Degree 

McGill University

Residency 

Pediatrics, Montreal Children's Hospital

Fellowship(s) 

Pediatric Pulmonology, Montreal Children's Hospital

Research

Research interests 

Children with lung diseases, such as asthma and cystic fibrosis, have excessive inflammation in their lungs. This often limits their ability to be physically active. I study how to calm down lung inflammation, boost immune defences, and improve physical performance. In our laboratory we are attempting to increase natural immunity to respiratory viral infections, to prevent people with chronic lung disease from becoming sicker when they catch a cold. The immune-boosting abilities of vitamin D are also being examined, as are the immune and performance enhancing properties of our novel whey protein supplement. And to help patients benefit from an active lifestyle, we are studying a new motivational program to encourage physical activity in patients with cystic fibrosis. 

Research foci 
  • Chronic lung disease;
  • Anti-viral defense;
  • Innate immunity;
  • Nutrition;
  • Exercise physiology.
Keywords 

Cystic fibrosis (CF), asthma, immune modulation, physical activity, translational research

Selected publications 

Dauletbaev N, Lam J, Eklove D, Lands LC. Ibuprofen modulates NF-κB but not IL-8 in cystic fibrosis respiratory epithelial cells. Respiration 79:234-242, 2010. 

Lands LC, Iskandar M (S), Beaudoin N, Meehan B, Dauletbaev N, Berthiaume Y. Dietary supplementation with pressurized whey in patients with cystic fibrosis. J of Medicinal Foods 13:77-82, 2010.

Saiman L, Anstead M, Mayer-Hamblette N, Lands LC, Kloster M, Hocevar-Trnka J, Goss CH, Rose LM, Burns JL, Marshall BC, Ratjen F. Effect of Azithromycin on Pulmonary Function in Patients with Cystic Fibrosis Uninfected with Pseudomonas aeruginosa: A Randomized Controlled Trial . JAMA 303(17):1707-1705, 2010.

Dauletbaev N, Eklove D, Mawji N, Iskandar M, Di Marco S, Gallouzi I, Lands LC. Both MKP-1 dependent and independent inhibition of p38 MAPK are required for efficient pharmacological down-regulation of IL-8. JBC 286 (18):15998-16007, 2011.

McIlwaine MP, Alarie N, Davidson GF, Lands LC, Ratjen F, Milner R, Owen B, Agnew JL. Long-term multi-centre randomised controlled study of high frequency chest wall oscillation versus positive expiratory pressure mask in cystic fibrosis. Thorax 68:746-751, 2013.