Myriam Srour, MD CM, FRCP(C), PhD
I have lived in 5 different countries
Hospital information
- Assistant professor, Division of Pediatric Neurology, Department of Pediatrics, Neurology and Neurosurgery, Faculty of Medicine, McGill University
- Pediatric Neurologist, Montreal Children’s Hospital, MUHC
- Junior Clinician-Scientist, Child Health and Human Development Program, Research Institute of the McGill Univerisity Health Center
- Pediatric Neurology Residency Program co-director McGill University, Montreal, Canada
Education
Biology, McGill University
McGill University
Pediatric Neurology, McGill University
Neurogenetics Fellowship, Université de Montréal PhD Molecular Biology, Université de Montréal
Research
My laboratory studies of the genetic causes of childhood neurodevelopmental disorders with a focus on structural brain disorders. Affected children can have important neurologic impairments, such as epilepsy, cerebral palsy or learning difficulties. In my previous work, I have identified genes responsible for a number of childhood neurologic diseases, including Joubert syndrome, intellectual disability and congenital mirror movements. Better understanding of causal genes will shed light on the mechanisms underlying these childhood neurologic disorders and will open avenues for treatment and prevention.
Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy. Srour M, Shimokawa N, Hamdan FF, Nassif C, Poulin C, Al Gazali L, Rosenfeld JA, Koibuchi N, Rouleau GA, Al Shamsi A, Michaud JL. Am J Hum Genet. 2017 May 4;100(5):824-830. doi: 10.1016/j.ajhg.2017.03.009. Epub 2017 Apr 20.PMID: 28434495 Gain-of-Function Mutations in RARB Cause Intellectual Disability with Progressive Motor Impairment. Srour M, Caron V, Pearson T, Nielsen SB, Lévesque S, Delrue MA, Becker TA, Hamdan FF, Kibar Z, Sattler SG, Schneider MC, Bitoun P, Chassaing N, Rosenfeld JA, Xia F, Desai S, Roeder E, Kimonis V, Schneider A, Littlejohn RO, Douzgou S, Tremblay A, Michaud JL. Hum Mutat. 2016 Aug;37(8):786-93. doi: 10.1002/humu.23004. Epub 2016 May 9. PMID: 27120018 Joubert Syndrome in French Canadians and Identification of Mutations in CEP104.Srour M, Hamdan FF, McKnight D, Davis E, Mandel H, Schwartzentruber J, Martin B, Patry L, Nassif C, Dionne-Laporte A, Ospina LH, Lemyre E, Massicotte C, Laframboise R, Maranda B, Labuda D, Décarie JC, Rypens F, Goldsher D, Fallet-Bianco C, Soucy JF, Laberge AM, Maftei C; Care4Rare Canada Consortium, Boycott K, Brais B, Boucher RM, Rouleau GA, Katsanis N, Majewski J, Elpeleg O, Kukolich MK, Shalev S, Michaud JL. Am J Hum Genet. 2015 Nov 5;97(5):744-53. doi: 10.1016/j.ajhg.2015.09.009. Epub 2015 Oct 17. PMID:26477546 Mutations in DCC cause congenital mirror movements. Srour M, Rivière JB, Pham JM, Dubé MP, Girard S, Morin S, Dion PA, Asselin G, Rochefort D, Hince P, Diab S, Sharafaddinzadeh N, Chouinard S, Théoret H, Charron F, Rouleau GA.Science. 2010 Apr 30;328(5978):592. doi: 10.1126/science.1186463. PMID: 20431009