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Dr. Nada Jabado
Brain Tumour Research
Research is in the field of pediatric brain tumours, more specifically in brain tumours from the astrocytic lineage. The main objective is to achieve a better characterization of molecular markers and pathways responsible for pediatric high grade astrocytoma formation in a large number of pediatric tumours.
 
Results will provide insight into genetic pathways involved in the initiation and progression of pediatric high grade astrocytomas and will likely provide a rational framework for the development of efficient interventional therapies.
  
Keywords
 
Paediatric high grade astrocytoma, genome and transcriptome analysis, protein analysis, laser capture microdissection, exome sequencing 
 
Recent Honours and Distinctions
 
In 2012, Dr. Jabado was distinguished by several awards and honours:
  • She received the Canadian Cancer Society William E. Rawls Award for excellence in cancer research. This honour is awarded each year by the National Council of the Canadian Cancer Society to a young investigator whose work has led to important advances in cancer control within the past decade.
  • She received the Maude Abbott Prize from the Faculty of Medicine at McGill. This prize recognizes outstanding women faculty members who excel in education, research or administration, with a focus on those at the early stages of their careers.
  • She was named “Researcher of the Month” by Canadians for Health Research.
  • She was profiled by Premières en affaires magazine as one of eight women who are innovative, inspiring trailblazers on the frontlines of strategic change in health care.
  • She received the Group Jean Coutu Best Care for Children Award in Research from the Montreal Children’s Hospital Foundation.
In 2011, Dr. Jabado was among the top researchers from across Canada chosen to participate in two initiatives funded by the Canadian Government. The Canadian Pediatric Cancer Genome Consortium and the Finding of Rare Disease Genes in Canada (FORGE Canada) team both aim to identify the genes that cause the most challenging types of cancer and rare disease in children, and find new treatments.

Dr. Nada Jabado’s research breakthrough with Dr. Jacek Majewski (McGill University) was identified in the December 15, 2010 issue of L’actualité as one of 35 inventions that will “change everything.” This research, published in Human Mutation in 2010, demonstrated that the sequencing of one person’s exome can permit effective research into mutations indicating a genetic disease, without the need to sequence an entire genome.

Related articles and videos
 
 
 
 
June 2010
An international first: a research team at MUHC/McGill validates the effectiveness of a rapid genome sequencing process for hereditary genetic diseases. +
 
Department (s)
 
Selected publications

Schwartzentruber J, Korshunov A, Liu XY, Jones DTW, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel JO, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann MU, Scheurlen W, Pekrun A, Frühwald MC, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel P, Kulozik AE, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins VP, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister SM, Jabado N. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature, 2012 Jan. [e-publication]
Jacob K, Quang-Khuong DA, Jones DT, Witt H, Lambert S, Albrecht S, Witt O, Vezina C, Shirinian M, Faury D, Garami M, Hauser P, Klekner A, Bognar L, Farmer JP, Montes JL, Atkinson J, Hawkins C, Korshunov A, Collins VP, Pfister SM, Tabori U, Jabado N. Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas. Clin Cancer Res 17(14):4650-4660, 2011.
Lalonde E, Albrecht S, Ha KC, Jacob K, Bolduc N, Polychronakos C, Dechelotte P, Majewski J, Jabado N. Unexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencing. Hum Mutat 31(8):918-23, 2010.
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