Larry C. Lands, MD, PhD; Director, Pediatric Respiratory Medicine, Pediatric Cystic Fibrosis Clinic, and Pediatric Pulmonary Function Laboratory

Pulmonology; Pediatric Pulmonary Function Laboratory
Fun fact about me 

I have a comic book collection.

I love working with children and their families because 
I enjoy listening to all the giggling.

Hospital information

Academic appointments 

Professor, Department of Pediatrics, Faculty of Medicine, McGill University 

Other appointments 
  • Canadian Thoracic Society Chair Research Committee   
  • Cystic Fibrosis Canada Chair Scientific Advisory Council  
  • CF Canada’s clinical research network, CFCanACT, Executive Committee member and co-chair, protocol review committee 
  • Associate Editor, Paediatric Respiratory Reviews 
  • Associate Editor, Pediatric Pulmonology 

Education

University 

B.Sc., Mathematics Major, Biology Minor, McGill University; PhD, Medical Sciences, McMaster University

Medical Degree 

McGill University

Residency 

Pediatrics, Montreal Children's Hospital

Fellowship(s) 

Pediatric Pulmonology, Montreal Children's Hospital

Research

Research interests 

Children with lung diseases, such as asthma and cystic fibrosis, have excessive inflammation in their lungs. This often limits their ability to be physically active. I study how to calm down lung inflammation, boost immune defences, and improve physical performance. In our laboratory we are attempting to increase natural immunity to respiratory viral infections, to prevent people with chronic lung disease from becoming sicker when they catch a cold. In clinical research we are examining a new technique to measure lung function in young infants known as oscillometry. We continue to study exercise ability and the factors limiting exercise in children with chronic disease. 

Research foci 
  • Chronic lung disease; 
  • Anti-viral defense; 
  • Innate immunity; 
  • Exercise physiology; 
  • Nutrtion 
Keywords 

Cystic fibrosis (CF), asthma, immune modulation, physical activity, translational research 

Selected publications 

Dauletbaev N, Cammisano M (S), Herscovitch K (S), Lands LC. Targeted stimulation of antiviral interferon-beta in airway epithelial cells and macrophages with minimal concomitant inflammation. J Immunol 195(6):2829-41, 2015. 

Dauletbaev N, Das M (S), Cammisano M (S), Koi C, Leigh R, Beaudoin T, Rousseau S, Lands LC. Viral load is high despite preserved interferon-beta response in rhinovirus-infected CF cells. PLoS ONE November 23; 10(11):e0143129. 2015.  

Mak, DYF, Sykes J, Stephenson AL, Lands LC.  The benefits of newborn screening for cystic fibrosis: The Canadian Experience. J CF 2016 May;15(3):302-8. 

Hebestreit H, Hulzebos EH, Schneiderman JE, Karila C, Boas SR, Kriemler S, Dwyer T, Sahlberg M, Urquhart DS, Lands LC, Ratjen F, Takken T, Varanistkaya L, Rücker V, Hebestreit A, Usemann J, Radtke T. Cardiopulmonary exercise testing provides additional prognostic information in cystic fibrosis. Am J Respir Crit Care Med 2019;199(8):987-995. 

Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele. N Engl J Med. 2019 Nov 7;381(19):1809-1819.